Jeffrey I. Gordon, M.D.

Dr. Robert J. Glaser Distinguished University Professor
Director, Center for Genome Sciences

jgordon@wustl.edu

Molecular Microbiology and Microbial Pathogenesis Program
Molecular Cell Biology Program
Developmental Biology Program

Education:

Oberlin College, A.B., 1969, Biology
University of Chicago, M.D., 1973, Medicine
Laboratory of Biochemistry, NCI, NIH, Post-doc, 1975–78, 1975–78

Positions and Honors:

1973–1975 — Intern & Junior Assistant Resident, Medicine, Barnes Hospital, St. Louis, MO
1975–1978 — Research Associate, Laboratory of Biochemistry, National Cancer Institute, NIH
1978–1979 — Senior Assistant Resident, Medicine, Barnes Hospital and Chief Medical Resident, Washington University Medical Service, John Cochran VA Hospital
1979–1981 — Fellow in Medicine (Gastroenterology), Washington University School of Medicine

Academic Positions (all at Washington University):

Asst. Prof. (1981–1984); Assoc. Prof. (1985–1987); Prof. (1987–1990) of Medicine and Biological Chemistry; Prof. and Head, Dept. Molecular Biology & Pharmacology (1991–2004); Director, Center for Genome Sciences (2004–present); Chair, Executive Council, Division of Biology and Biomedical Sciences (the Division oversees all graduate education in the biological sciences at our university) (1994–2003)

Recent Meetings Organized

Chair, 4th International Conference on Systems Biology, 2003; NAS Sackler Colloquium ‘Tapestry of Life — lateral transfer of heritable elements’ (2005)

Honors:

1969 A.B. cum laude, with high honors in Biology
1973 M.D. with honors; Alpha Omega Alpha; Upjohn Achievement Award
1981-1984 John A. and George L. Hartford Foundation Fellowship
1985-1990 Established Investigator, American Heart Association
1989 Member, Association of American Physicians
1990 American Federation for Clinical Research Young Investigator Award
1990 National Institute of Diabetes and Digestive and Kidney Diseases Young Scientist Award
1992 American Gastroenterological Association (AGA) Distinguished Achievement Award
1992 Fellow, American Association for the Advancement of Science
1994 Marion Merrell Dow Distinguished Prize in Gastrointestinal Physiology
1998 Wellcome Visiting Professor in the Basic Medical Sciences
1999 Morton I. Grossman Distinguished Lecturer, AGA
2001 Fellow, American Academy of Microbiology
2001 Member, National Academy of Sciences
2002 Dr. Robert J. Glaser Distinguished University Professorship
2003 Janssen/AGA Award for Sustained Achievement in Digestive Sciences
2003 Horace W. Davenport Distinguished Lectureship, Am. Physiol. Assoc.
2004 Member, American Academy of Arts & Sciences
2005 ASM Lecturer, American Society of Microbiology

Teaching Awards:

Distinguished Teaching Awards, Washington Univ. Sch. of Med. (1991, 1992, 1993, 1994); Outstanding Faculty Mentor Award, Graduate Student Council; Washington University (2000). Mentored 45 PhD and MD/PhD students and 44 post-doctoral fellows

Current/Recent Advisory Committees:

National Research Council committee on “Metagenomics: Challenges and Functional Applications “(2005–2007); Science and Technology Advisory Committee, Pfizer (2003-present); Massachusetts General Hospital Scientific Advisory Committee (2003-2006); member then Chair, Burroughs Wellcome Fund Advisory Board on “Interfaces Between the Physical & Biomedical Sciences Program” (1996-2002); Member of Council, National Institute of Diabetes and Digestive and Kidney Diseases (1999-2002).

Selected Publications (from a total of 382)

Bry, L., Falk, P.G., Midtvedt, T., and Gordon, J.I. A model of host-microbial interactions in an open mammalian ecosystem. Science 273: 1380-1383 (1996).
Hooper, L., Xu, J., Falk, P., Midtvedt, T.,Gordon, J.I. A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem. Proc. Natl. Acad. Sci. USA 96: 9833-9838 (1999).
Hooper, L., Wong, M., Thelin, A., Hansson, L., Falk, P., and Gordon, J.I. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291: 881-884 (2001).
Xu, J., Bjursell, M.K., Himrod, J., Deng, S. Carmichael, L.K., Chiang, H.C., Hooper, L.V., Gordon, J.I. A genomic view of our symbiosis with Bacteroides thetaiotaomicron. Science, 299: 2074-2076 (2003).
Hooper, L.V., Stappenbeck, T.S., Hong, C.V., Gordon, J.I. Angiogenins: a new class of microbicidal proteins involved in innate immunity Nature Immunol 4:269-273 (2003).
Bäckhed, F., Ding, H., Wang, T., Hooper, L.V., Koh,G. Y., Nagy, A., Semenkovich, C.F. Gordon, J. I. The gut microbiota as an environmental factor that regulates fat storage, Proc. Natl. Acad. Sci. USA 101: 15718-15723 (2004).
Sonnenburg, J.L., Xu, J., Leip, D.D., Chen, C-H., Westover, B. P., Weatherford, J., Buhler, J.D., Gordon, J. I. Glycan foraging in vivo by an intestine-adapted bacterial symbiont, Science 307:1955-1959 (2005)
Ley, R. E., Backhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., and Gordon, J. I. Obesity alters gut microbial ecology, Proc. Natl. Acad. Sci. USA 102: 11070-11075 (2005).
Ley, R., Peterson, D. A., and Gordon, J.I. Ecological and evolutionary forces that shape microbial diversity and genome content in the human intestine. Cell124: 837-848 (2006).
Sonnenburg, E.D., Sonnenburg, J.L., Manchester, J.K., Hansen, E.E., Chiang, H.C., and Gordon, J.I. A hybrid two component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism. Proc. Natl. Acad. Sci. USA 103 8834-8839 (2006).
Samuel, B. S. and Gordon, J.I. A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism. Proc. Natl. Acad. Sci. USA 103: 10011-10016 (2006)
Rawls, J.F., Mahowald, M.A., Ley, R.E., Gordon, J.I. Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell, 127: 423-33 (2006).
Sonnenburg, J., Chen, C., Gordon, J.I. Genomic and metabolic studies of the impact of probiotics on the gut microbiota and host. PLoS Biology 4: 2213-2226 (2006).
Ley, R.E., Turnbaugh, P.J., Klein, S., and Gordon, J.I. Human gut microbes linked to obesity. Nature 444: 1022-1023 (2006).
Turnbaugh, P.J., Ley, R.E., Mahowald, M., Magrini, V., Mardis, E.R. and Gordon, J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027-1031 (2006).
Bäckhed, F., Manchester, J.K., Semenkovich, C.F., andGordon, J.I. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc. Natl. Acad. Sci. USA 104: 979-984 (2007).
Xu, J., Mahowald, M.A., Ley, R.E., Lozupone, C.A., Hamady, M., Martens, E.C., Henrissat, B., Coutinho, P.M., Minx, P., Latreille, P., Cordum, H., Van Brunt, A., Kim, K., Fulton, R.S., Fulton, L.A., Clifton, S.W., Wilson, R.K., Knight, R.D., and Gordon, J.I. Evolution of symbiotic bacteria in the distal human intestine. PLoS Biol. 5: e156 (2007).
Samuel, B.S., Hansen, E.E., Manchester, J.K., Coutinho, P.M., Henrissat, B., Fulton, R., Latreille, P.L., Kim, K., Wilson, R.K., and Gordon, J.I. Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut. Proc. Natl. Acad. Sci. USA 104: 10643-10648 (2007).